InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PRKRA

Summary

InnateDB Gene

IDBG-640208.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKRA

Gene Name

Interferon-inducible double stranded RNA-dependent protein kinase activator A

Synonyms

PACT

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001096

Encoded Proteins

IDBP-692437

Interferon-inducible double stranded RNA-dependent protein kinase activator A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25784705

[Homo sapiens] The G3BP1-CAPRIN1-PRKRA complex represents a new mode of PRKRA activation and links stress responses with innate immune activation through PRKRA without a requirement for foreign double-stranded RNA pattern recognition.

PMID 26608320

[Homo sapiens] A defective interfering RNA isolated from the Hu-191 vaccine strain of measles virus is sensed by PRKRA and DDX58 to initiate an innate antiviral response.

PMID 26454002

[Homo sapiens] DDX3X participates in antiviral innate immunity by controlling translation of PRKRA.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180228:
This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:18433086-18449877

Strand

Forward strand

Band

Transcripts

ENSBTAT00000001451

ENSBTAP00000001451

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0016301	kinase activity
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0006950	response to stress
GO:0016310	phosphorylation
GO:0030422	production of siRNA involved in RNA interference
GO:0031047	gene silencing by RNA
GO:0034599	cellular response to oxidative stress
GO:0042473	outer ear morphogenesis
GO:0042474	middle ear morphogenesis
GO:0048705	skeletal system morphogenesis
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway