Version 5.4
| Bos taurus Gene: JUN | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-638846.3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Symbol | JUN | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Name | transcription factor AP-1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000004037 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
transcription factor AP-1
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| Protein Structure | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] JUN interacts with NFATC2 to synergistically activate interleukin-2 (IL2) transcription in T cells, a cytokine that acts as an autocrine growth factor during an immune response to bacterial and viral infection, as well as tumourigenesis.
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| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177606:
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 3:87841042-87843087 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 239 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NETPATH |
Alpha6Beta4Integrin pathway
AndrogenReceptor pathway
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
Wnt pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL1 pathway
IL2 pathway
IL5 pathway
IL6 pathway
RANKL pathway
Prolactin pathway
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| REACTOME |
Activation of the AP-1 family of transcription factors pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Pre-NOTCH Transcription and Translation pathway
Cellular responses to stress pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Pre-NOTCH Expression and Processing pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Cellular Senescence pathway
Signaling by NOTCH pathway
Activated TLR4 signalling pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Oxidative Stress Induced Senescence pathway
FCERI mediated MAPK activation pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Oxidative Stress Induced Senescence pathway
Activation of the AP-1 family of transcription factors pathway
MAPK targets/ Nuclear events mediated by MAP kinases pathway
Cellular responses to stress pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MAP kinase activation in TLR cascade pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Cellular Senescence pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
Toll-Like Receptors Cascades pathway
MyD88 dependent cascade initiated on endosome pathway
Activated TLR4 signalling pathway
MyD88-independent cascade pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
FCERI mediated MAPK activation pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
GnRH signaling pathway pathway
Colorectal cancer pathway
Wnt signaling pathway pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
MAPK signaling pathway pathway
B cell receptor signaling pathway pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Leishmaniasis pathway
Chagas disease (American trypanosomiasis) pathway
Osteoclast differentiation pathway
Renal cell carcinoma pathway
ErbB signaling pathway pathway
T cell receptor signaling pathway pathway
Wnt signaling pathway pathway
Toll-like receptor signaling pathway pathway
Colorectal cancer pathway
GnRH signaling pathway pathway
MAPK signaling pathway pathway
Focal adhesion pathway
B cell receptor signaling pathway pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Leishmaniasis pathway
Osteoclast differentiation pathway
Chagas disease (American trypanosomiasis) pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
EGF signaling pathway pathway
TNFR1 signaling pathway pathway
TGF-beta signaling pathway
PDGF signaling pathway pathway
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
EGF signaling pathway pathway
TNFR1 signaling pathway pathway
TGF-beta signaling pathway
PDGF signaling pathway pathway
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| PID NCI |
Nephrin/Neph1 signaling in the kidney podocyte
CD40/CD40L signaling
Calcium signaling in the CD4+ TCR pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Validated transcriptional targets of AP1 family members Fra1 and Fra2
LPA receptor mediated events
Regulation of retinoblastoma protein
IL2-mediated signaling events
Validated nuclear estrogen receptor alpha network
Presenilin action in Notch and Wnt signaling
IL1-mediated signaling events
Downstream signaling in naïve CD8+ T cells
S1P2 pathway
Direct p53 effectors
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
ErbB1 downstream signaling
ATF-2 transcription factor network
Signaling events mediated by focal adhesion kinase
IL12 signaling mediated by STAT4
Regulation of nuclear beta catenin signaling and target gene transcription
Integrin-linked kinase signaling
AP-1 transcription factor network
Glucocorticoid receptor regulatory network
RAC1 signaling pathway
FGF signaling pathway
Endothelins
BCR signaling pathway
ErbB2/ErbB3 signaling events
JNK signaling in the CD4+ TCR pathway
CDC42 signaling events
Regulation of nuclear SMAD2/3 signaling
HIF-1-alpha transcription factor network
Signaling mediated by p38-alpha and p38-beta
Signaling events regulated by Ret tyrosine kinase
RhoA signaling pathway
Regulation of Androgen receptor activity
Fc-epsilon receptor I signaling in mast cells
FOXA1 transcription factor network
PDGFR-alpha signaling pathway
PDGFR-beta signaling pathway
IL6-mediated signaling events
Regulation of Telomerase
Osteopontin-mediated events
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| Cross-References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| TrEMBL | Q08DH1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | 280831 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniGene | Bt.11159 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_001077827 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| EMBL | BC123753 DAAA02008758 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GenPept | AAI23754 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 280831 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||