InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PPM1F

Summary

InnateDB Gene

IDBG-637531.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPM1F

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006938

Encoded Proteins

IDBP-689555

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100034:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:73955266-73967283

Strand

Forward strand

Band

Transcripts

ENSBTAT00000009109

ENSBTAP00000009109

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0033192	calmodulin-dependent protein phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0006470	protein dephosphorylation
GO:0010628	positive regulation of gene expression
GO:0010634	positive regulation of epithelial cell migration
GO:0010811	positive regulation of cell-substrate adhesion
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0035690	cellular response to drug
GO:0035970	peptidyl-threonine dephosphorylation
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045927	positive regulation of growth
GO:0050921	positive regulation of chemotaxis
GO:0051496	positive regulation of stress fiber assembly
GO:0051894	positive regulation of focal adhesion assembly
GO:0097193	intrinsic apoptotic signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0043234	protein complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000100034

View Gene Order

ENSMUSG00000026181

View Gene Order

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

XM_002694701 XM_870537

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas