InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: UBE2I

Summary

InnateDB Gene

IDBG-634261.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2I

Gene Name

SUMO-conjugating enzyme UBC9

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000038866

Encoded Proteins

IDBP-686028

SUMO-conjugating enzyme UBC9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26348439

[Mus musculus] Baiap2l1 recruits Ube2i to sumoylate Pcbp2, which causes its cytoplasmic translocation during viral infection and the sumoylated Pcbp2 associates with Mavs to initiate its degradation, leading to downregulation of antiviral responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103275:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:1041085-1048106

Strand

Forward strand

Band

Transcripts

ENSBTAT00000056739

ENSBTAP00000047838

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 280 interaction(s) predicted by orthology.

Predicted by orthology
Total	280 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016874	ligase activity
GO:0016881	acid-amino acid ligase activity
GO:0019789	SUMO ligase activity
GO:0019899	enzyme binding
GO:0043398	HLH domain binding
GO:0044822	poly(A) RNA binding
GO:0071535	RING-like zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0008152	metabolic process
GO:0045892	negative regulation of transcription, DNA-templated