Bos taurus Gene: TLR3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-628571.3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Symbol | TLR3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Name | toll-like receptor 3 precursor | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000008682 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Encoded Proteins |
toll-like receptor 3 precursor
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Protein Structure | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Summary |
[Homo sapiens] TLR3-type II IFN signalling cooperates with the RIG-I/MDA5-type I IFN axes for efficient innate antiviral immune responses.
[Homo sapiens] TLR3-dependent antiviral pathway is negatively regulated by activated F2RL1 leading to blunted expression of TLR3/IRF3 driven genes, as well as activation of IRF3 and STAT1.
[Homo sapiens] TLR3, TLR2, or TLR4 cooperate with proteinase-activated receptors (PARs) for activation of nuclear factor-kappaB-dependent signalling in mucosal epithelial cell lines.
[Homo sapiens] TLR3-induced proapoptotic signalling involves TICAM1 (TRIF)-dependent activation of CASP8 and is under the control of inhibitor of apoptosis proteins (IAPs) in melanoma cells.
[Homo sapiens] TLR3 is activated by poly(I:C) and this induces cytokine production through a signalling pathway dependent on MyD88.
[Homo sapiens] TLR3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter 1 (TICAM1) inducing IFN-beta.
[Homo sapiens] TLR3 dimerizes when it binds dsRNA and this is essential for ligand binding. Although the three TLR3 contact sites individually interact weakly with their binding partners, together they form a high affinity ligand-receptor complex.
[Homo sapiens] TLR3 deletion dramatically enhanced the development of elastic lamina damage after collar-induced injury, indicating that TLR3 signalling plays a protective role in arterial vessel wall.
[Homo sapiens] TLR3 activation by Poly(I:C) in the endothelial cells induces Poly(I:C) dose- and time-dependent cell apoptosis. Specifically, TLR3 stimulation triggered the signalling of both extrinsic and intrinsic apoptotic pathways.
[Homo sapiens] TLR3 requires proteolytic processing in endolysosome by asparagine endopeptidase and cathepsin in the endolysosome to initiate signalling in response to DNA. (Demonstrated in murine model)
[Homo sapiens] TLR3 expression is inducible by LPS via TLR4-MYD88-IRAK-TRAF6-NFKB dependent signalling pathway.
[Homo sapiens] TLR3 is necessary to establish an antiviral state in hepatocytes infected with hepatitis C Virus. HCV envelope proteins counteract the antiviral host defence by inhibiting the expression of TLR3.
[Homo sapiens] TLR3 signalling is enhanced by the presence of viral double-strand RNA-binding proteins.
[Homo sapiens] TLR3-TICAM1-mediated signalling pathway plays an essential role in the anti-viral response against poliovirus infection. (Demonstrated in mice)
[Homo sapiens] TLR3 is constitutively expressed in spermatogonia and spermatocytes, and has the ability to activate anti-viral responses. (Demonstrated in mice)
[Homo sapiens] Upon engagement with its ligand, dsRNA, TLR3 possesses the ability to recruit CASP8 and RIPK1 to induce apoptosis.
[Homo sapiens] Activation of TLR3 with poly(I:C) mediates antiviral immunity that diminishes coronavirus production in macrophages. (Demonstrated in mice)
[Homo sapiens] Upregulation of TLR3 in intestinal epithelia during infancy may contribute to age-dependent susceptibility to rotavirus infection. (Demonstrated in mice)
[Homo sapiens] TLR3 activation differentially regulates phagocytosis of bacteria and apoptotic neutrophils by peritoneal macrophages. (Demonstrated in mice)
[Homo sapiens] TLR3 is more efficiently activated by high molecular mass than by low molecular weight poly(I:C).
[Homo sapiens] TLR3-mediated antibody response to Chikungunya virus plays a key role in its infection, replication and pathology.
[Homo sapiens] Intracellular/endocytic TLR3 interacts with SCARF 1 in the presence of Poly I:C to boost TLR3-mediated inflammatory signalling and stimulate cytokine production in macrophages.
[Homo sapiens] Signalling through both DDX58 and TLR3 is important for interferon induction by influenza A virus in alveolar epithelial cells.
[Homo sapiens] Bluetongue virus activates TLR3/interferons signalling pathway resulting in the inhibition of human immunodeficiency virus in macrophages.
[Mus musculus] Tlr3 deletion dramatically enhanced the development of elastic lamina damage after collar-induced injury, indicating that Tlr3 signalling plays a protective role in arterial vessel wall.
[Mus musculus] Tlr3 activation by Poly(I:C) in the endothelial cells induces Poly(I:C) dose- and time-dependent cell apoptosis. Specifically, Tlr3 stimulation triggered the signalling of both extrinsic and intrinsic apoptotic pathways.
[Mus musculus] Tlr3 requires proteolytic processing in endolysosome by asparagine endopeptidase and cathepsin in the endolysosome to initiate signalling in response to DNA.
[Mus musculus] Tlr3 expression is inducible by LPS via Tlr4-Myd88-Irak-Traf6-NfkB dependent signalling pathway. (Demonstrated in human)
[Mus musculus] Tlr3 is necessary to establish an antiviral state in hepatocytes infected with hepatitis C Virus. HCV envelope proteins counteract the antiviral host defence by inhibiting the expression of Tlr3. (Demonstrated in human)
[Mus musculus] TLR3 signalling is enhanced by the presence of viral double-strand RNA-binding proteins. (Demonstrated in human)
[Mus musculus] Tlr3-Ticam1-mediated signalling pathway plays an essential role in the anti-viral response against poliovirus infection.
[Mus musculus] Tlr3 is constitutively expressed in spermatogonia and spermatocytes, and has the ability to activate anti-viral responses.
[Mus musculus] Upon engagement with its ligand, dsRNA, Tlr3 possesses the ability to recruit Casp8 and Ripk1 to induce apoptosis. (Demonstrated in human)
[Mus musculus] Activation of Tlr3 with poly(I:C) mediates antiviral immunity that diminishes coronavirus production in macrophages.
[Mus musculus] Upregulation of Tlr3 in intestinal epithelia during infancy may contribute to age-dependent susceptibility to rotavirus infection.
[Mus musculus] TLR3 activation differentially regulates phagocytosis of bacteria and apoptotic neutrophils by peritoneal macrophages.
[Mus musculus] Tlr3 contributes to the control of activated endogenous retroviruses (ERVs) and ERV-induced tumours.
[Mus musculus] Wdfy1 is a crucial adaptor protein in the Tlr3/4 signalling pathway. Wdfy1 interacts with Tlr3 and Tlr4 and mediates the recruitment of Ticam1 to these receptors.
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Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164342:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 27:15232459-15243399 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
REACTOME |
RIP-mediated NFkB activation via ZBP1 pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
TRAF6 mediated induction of TAK1 complex pathway
IKK complex recruitment mediated by RIP1 pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
TRIF-mediated programmed cell death pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Trafficking and processing of endosomal TLR pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Cytosolic sensors of pathogen-associated DNA pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Innate Immune System pathway
Trafficking and processing of endosomal TLR pathway
TRAF6 mediated induction of TAK1 complex pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
Immune System pathway
Toll-Like Receptors Cascades pathway
Cytosolic sensors of pathogen-associated DNA pathway
TRIF-mediated programmed cell death pathway
RIP-mediated NFkB activation via ZBP1 pathway
Activated TLR4 signalling pathway
IKK complex recruitment mediated by RIP1 pathway
MyD88-independent cascade pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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KEGG |
Toll-like receptor signaling pathway pathway
Hepatitis C pathway
Toll-like receptor signaling pathway pathway
Hepatitis C pathway
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INOH | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
PID NCI |
Endogenous TLR signaling
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Cross-References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
TrEMBL | A5H649 Q56GY7 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Entrez Gene | 281535 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
UniGene | Bt.12298 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
RefSeq | NM_001008664 XM_005225954 XM_005225955 XM_005225956 XM_005225957 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
EMBL | AY957624 DAAA02060200 EF076741 EF076742 EF076745 EF076746 EF076749 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
GenPept | AAX56981 ABN71659 ABN71660 ABN71663 ABN71664 ABN71667 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | 281535 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||