Mus musculus Gene: Il1a
Summary
InnateDB Gene IDBG-57450.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol Il1a
Gene Name Interleukin-1 alpha
Synonyms Il-1a
Species Mus musculus
Ensembl Gene ENSMUSG00000027399
Encoded Proteins
Interleukin-1 alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Under acidic conditions both pro-inflammatory forms of Il1a and Il1b are regulated independently of the NLRP3 inflammasome.
In response to adenovirus infection, the IL1A-IL1R1-CXCR2 signalling axis cooperates with complement to recruit Ly-6G+7/4+ polymorphonuclear leukocytes to the splenic marginal zone (MZ) in the proximity of virus-containing MARCO+ residential MZ macrophages, which are subsequently eliminated.
NLRP3 inflammasome formation is dispensable for alum-induced innate immunity but Il1a and Il1b are both necessary for alum-induced neutrophil influx in vivo.
Il1a directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] Interleukin-1 (IL1A/IL1B) plays a key role in the interaction between local vessel wall cells and invading monocytes to multiply cholesterol-triggered inflammation in the vessel wall.
[Homo sapiens] IFNG interferes with the IL-1/NFKBIZ axis in β-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFNG and IL22, and diminished production of IL17A.
[Homo sapiens] CASP4 is a critical regulator of noncanonical inflammasome activation that initiates defence against bacterial pathogens in primary macrophages by mediating cell death and IL1A release
[Homo sapiens] IL1A directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115008:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer\'s disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:129299610-129309972
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000028882 ENSMUSP00000028882
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 1 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005149 interleukin-1 receptor binding
GO:0005507 copper ion binding
Biological Process
GO:0001660 fever generation
GO:0002248 connective tissue replacement involved in inflammatory response wound healing
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0008285 negative regulation of cell proliferation
GO:0010469 regulation of receptor activity
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0019221 cytokine-mediated signaling pathway
GO:0032755 positive regulation of interleukin-6 production
GO:0034605 cellular response to heat
GO:0035234 ectopic germ cell programmed cell death
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0045840 positive regulation of mitotic nuclear division
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046688 response to copper ion
GO:0050714 positive regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0051781 positive regulation of cell division
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2000391 positive regulation of neutrophil extravasation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Bos taurus
Homo sapiens
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Interleukin-1 processing pathway
Signaling by Interleukins pathway
Cytokine Signaling in Immune system pathway
Interleukin-1 signaling pathway
Immune System pathway
Interleukin-1 family signaling pathway
KEGG
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Necroptosis pathway
Cellular senescence pathway
Osteoclast differentiation pathway
Hematopoietic cell lineage pathway
Non-alcoholic fatty liver disease (NAFLD) pathway
AGE-RAGE signaling pathway in diabetic complications pathway
Type I diabetes mellitus pathway
Prion diseases pathway
Salmonella infection pathway
Pertussis pathway
Leishmaniasis pathway
Tuberculosis pathway
Measles pathway
Influenza A pathway
Inflammatory bowel disease (IBD) pathway
Rheumatoid arthritis pathway
Graft-versus-host disease pathway
Fluid shear stress and atherosclerosis pathway
INOH
GPCR signaling-cholera toxin-.owl pathway
IL-1 JNK.owl pathway
IL-1 p38.owl pathway
GPCR signaling-G alpha s Epac and ERK-.owl pathway
GPCR signaling-pertussis toxin-.owl pathway
GPCR signaling-G alpha q-.owl pathway
IL-1 NFkB.owl pathway
GPCR signaling-G alpha i-.owl pathway
GPCR signaling-G alpha s PKA and ERK-.owl pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
IL1 pathway
REACTOME
Interleukin-1 processing pathway
Cytokine Signaling in Immune system pathway
Signaling by Interleukins pathway
Interleukin-1 family signaling pathway
Interleukin-1 signaling pathway
Immune System pathway
Cellular responses to external stimuli pathway
Cellular responses to stress pathway
Interleukin-1 family signaling pathway
Signaling by Interleukins pathway
Interleukin-1 processing pathway
Immune System pathway
Interleukin-10 signaling pathway
Interleukin-1 signaling pathway
Cellular Senescence pathway
Interleukin-4 and Interleukin-13 signaling pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Cytokine Signaling in Immune system pathway
KEGG
MAPK signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
Necroptosis pathway
Cellular senescence pathway
Osteoclast differentiation pathway
Hematopoietic cell lineage pathway
Non-alcoholic fatty liver disease (NAFLD) pathway
AGE-RAGE signaling pathway in diabetic complications pathway
Type I diabetes mellitus pathway
Prion diseases pathway
Salmonella infection pathway
Pertussis pathway
Leishmaniasis pathway
Tuberculosis pathway
Measles pathway
Influenza A pathway
Inflammatory bowel disease (IBD) pathway
Rheumatoid arthritis pathway
Graft-versus-host disease pathway
Fluid shear stress and atherosclerosis pathway
INOH
GPCR signaling-cholera toxin-.owl pathway
IL-1 JNK.owl pathway
IL-1 p38.owl pathway
GPCR signaling-G alpha s Epac and ERK-.owl pathway
GPCR signaling-pertussis toxin-.owl pathway
GPCR signaling-G alpha q-.owl pathway
IL-1 NFkB.owl pathway
GPCR signaling-G alpha i-.owl pathway
GPCR signaling-G alpha s PKA and ERK-.owl pathway
PID NCI
IL1-mediated signaling events
Validated transcriptional targets of deltaNp63 isoforms
a6b1 and a6b4 Integrin signaling
Cross-References
SwissProt P01582
TrEMBL Q3U0Y6
UniProt Splice Variant
Entrez Gene 16175
UniGene
RefSeq NM_010554 XM_006498793 XM_006498794
OMIM
CCDS CCDS16725
HPRD
IMGT
MGI ID MGI:96542
MGI Symbol Il1a
EMBL AF010237 AK156449 AY902318 BC003727 CH466519 X01450
GenPept AAC28999 AAH03727 AAX90603 BAE33715 CAA25682 EDL28237
RNA Seq Atlas 16175