Mus musculus Gene: Ap3b1
Summary
InnateDB Gene IDBG-54591.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol Ap3b1
Gene Name AP-3 complex subunit beta-1
Synonyms AP-3; AU015684; beta3A; C78395; Hps2; pe; pearl; rim2
Species Mus musculus
Ensembl Gene ENSMUSG00000021686
Encoded Proteins
AP-3 complex subunit beta-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Ap3b1 (AP-3), a lysosome-related organelle trafficking and biogenesis protein, is required for the production of pro-inflammatory cytokines in plasmacytoid dendritic cells upon recognition of viral nucleic acids by endosomal Tlr7 or Tlr9.
Ap3b1 is crucial for the trafficking of Tlr9 to specific endosomal compartments for the induction of type I interferon.
Cytokine activation as a result of Tlr2 stimulation is mediated by the phagosomal trafficking molecule Ap3b1 (AP-3).
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] AP3B1 (AP-3), a lysosome-related organelle trafficking and biogenesis protein, is required for the production of pro-inflammatory cytokines in plasmacytoid dendritic cells upon recognition of viral nucleic acids by endosomal TLR7 or TLR9.
[Homo sapiens] AP3B1 is crucial for the trafficking of TLR9 to specific endosomal compartments for the induction of type I interferon.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132842:
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:94358960-94566317
Strand Forward strand
Band C3
Transcripts
ENSMUST00000022196 ENSMUSP00000022196
ENSMUST00000220505
ENSMUST00000221206
ENSMUST00000222383
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 67 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0019903 protein phosphatase binding
GO:0030742 GTP-dependent protein binding
Biological Process
GO:0006622 protein targeting to lysosome
GO:0006829 zinc II ion transport
GO:0006886 intracellular protein transport
GO:0007596 blood coagulation
GO:0008089 anterograde axonal transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0019882 antigen processing and presentation
GO:0032438 melanosome organization
GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib
GO:0048490 anterograde synaptic vesicle transport
GO:0051138 positive regulation of NK T cell differentiation
Cellular Component
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016020 membrane
GO:0030117 membrane coat
GO:0030123 AP-3 adaptor complex
GO:0030131 clathrin adaptor complex
GO:0030665 clathrin-coated vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:1904115 axon cytoplasm
Orthologs
Species
Bos taurus
Homo sapiens
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Golgi Associated Vesicle Biogenesis pathway
Vesicle-mediated transport pathway
Membrane Trafficking pathway
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
KEGG
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Golgi Associated Vesicle Biogenesis pathway
Vesicle-mediated transport pathway
Clathrin derived vesicle budding pathway
Membrane Trafficking pathway
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
Golgi Associated Vesicle Biogenesis pathway
Diseases of signal transduction pathway
Oncogenic MAPK signaling pathway
Signaling by BRAF and RAF fusions pathway
Vesicle-mediated transport pathway
Disease pathway
Membrane Trafficking pathway
trans-Golgi Network Vesicle Budding pathway
KEGG
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt Q9Z1T1
TrEMBL
UniProt Splice Variant
Entrez Gene 11774
UniGene
RefSeq NM_009680 XM_006517523
OMIM
CCDS CCDS26693
HPRD
IMGT
MGI ID MGI:1333879
MGI Symbol Ap3b1
EMBL AC122373 AC123043 AF103809 AF255566 AF255567 AF255568 AF255569 AF255570 AF255571 AF255572 AF255573 AF255574 AF255575 AF255576 AF255577 AF255578 AF255579 AF255580 AF255581 AF255582 AF255583 AF255584 AF255585 AF255586 AF255587 AF255588 AF255589 BC015068
GenPept AAC78338 AAG23622 AAH15068
RNA Seq Atlas 11774