Homo sapiens Gene: IFNG
Summary
InnateDB Gene IDBG-45916.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFNG
Gene Name interferon, gamma
Synonyms IFG; IFI;
Species Homo sapiens
Ensembl Gene ENSG00000111537
Encoded Proteins
interferon, gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
The combined treatment of IFNG with 1,25-dihydroxyvitamin D3 (1,25-D3) synergistically enhances nitric oxide (NO) synthesis and NOS2 expression induced by Mycobacterium tuberculosis (MTB) or by its purified protein derivatives in human monocyte-derived macrophages.
IFNG mediates DUOX2 dual oxidase expression via a STAT-independent signalling pathway and providing insights into a novel IFNG signalling pathway with potential importance for regulation of host defence responses.
IFNG is crucial for immunity against intracellular pathogens and for tumour control and it is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response.
IFN gamma creates a primed chromatin environment in macrophages to augment TLR-induced gene transcription.
IFNG interferes with the IL-1/NFKBIZ axis in β-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFNG and IL22, and diminished production of IL17A.
Primary γδ T cells provide an early source of IFNG during dengue virus (DV) infection and target DV-infected cells. Monocytes also participate as accessory cells that sense DV infection and amplify the cellular immune response in an IL18-dependent manner.
DEFB103A and RNASE7 are induced in human umbilical endothelial cells (HUVECs) by classical inflammatory cytokines such as: IFNG, IL1B and TNF.
IFNG primes mast cells for enhanced anti-bacterial and pro-inflammatory responses to Staphylococcus aureus, partially mediated by ITGB1.
Entrez Gene
Summary This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:68154768-68159747
Strand Reverse strand
Band q15
Transcripts
ENST00000229135 ENSP00000229135
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 9 [view]
Protein-DNA 19 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005133 interferon-gamma receptor binding
GO:0005515 protein binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001781 neutrophil apoptotic process
GO:0002026 regulation of the force of heart contraction
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002250 adaptive immune response
GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0006925 inflammatory cell apoptotic process
GO:0006928 cellular component movement
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0007050 cell cycle arrest
GO:0007166 cell surface receptor signaling pathway
GO:0008285 negative regulation of cell proliferation
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0019882 antigen processing and presentation
GO:0030593 neutrophil chemotaxis
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031642 negative regulation of myelination
GO:0032224 positive regulation of synaptic transmission, cholinergic
GO:0032700 negative regulation of interleukin-17 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032747 positive regulation of interleukin-23 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0042102 positive regulation of T cell proliferation
GO:0042493 response to drug
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042742 defense response to bacterium
GO:0042832 defense response to protozoan
GO:0044130 negative regulation of growth of symbiont in host
GO:0044146 negative regulation of growth of symbiont involved in interaction with host
GO:0045080 positive regulation of chemokine biosynthetic process
GO:0045084 positive regulation of interleukin-12 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045410 positive regulation of interleukin-6 biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045666 positive regulation of neuron differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045785 positive regulation of cell adhesion
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050776 regulation of immune response
GO:0050796 regulation of insulin secretion
GO:0050954 sensory perception of mechanical stimulus
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051607 defense response to virus
GO:0051712 positive regulation of killing of cells of other organism
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060550 positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
GO:0060552 positive regulation of fructose 1,6-bisphosphate metabolic process
GO:0060557 positive regulation of vitamin D biosynthetic process
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity
GO:0071222 cellular response to lipopolysaccharide
GO:0071351 cellular response to interleukin-18
GO:0072308 negative regulation of metanephric nephron tubule epithelial cell differentiation
GO:0097191 extrinsic apoptotic signaling pathway
GO:0098908 regulation of neuronal action potential
GO:2000309 positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2000345 regulation of hepatocyte proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Immune System pathway
Interferon gamma signaling pathway
Regulation of IFNG signaling pathway
KEGG
Proteasome pathway
Cytokine-cytokine receptor interaction pathway
Regulation of autophagy pathway
TGF-beta signaling pathway pathway
Osteoclast differentiation pathway
Antigen processing and presentation pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
T cell receptor signaling pathway pathway
Type I diabetes mellitus pathway
Leishmaniasis pathway
Chagas disease (American trypanosomiasis) pathway
African trypanosomiasis pathway
Malaria pathway
Toxoplasmosis pathway
Amoebiasis pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Graft-versus-host disease pathway
INOH
GPCR signaling pathway
IFN gamma signaling pathway
JAK STAT pathway and regulation pathway
PID BIOCARTA
The 41bb-dependent immune response [Biocarta view]
No2-dependent il-12 pathway in nk cells [Biocarta view]
Chaperones modulate interferon signaling pathway [Biocarta view]
Il12 and stat4 dependent signaling pathway in th1 development [Biocarta view]
Ifn gamma signaling pathway [Biocarta view]
PID NCI
Calcium signaling in the CD4+ TCR pathway
IL2-mediated signaling events
IL27-mediated signaling events
Downstream signaling in nave CD8+ T cells
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
ATF-2 transcription factor network
IL12 signaling mediated by STAT4
AP-1 transcription factor network
Glucocorticoid receptor regulatory network
IL23-mediated signaling events
SHP2 signaling
Regulation of Telomerase
IFN-gamma pathway
Cross-References
SwissProt P01579
TrEMBL A1Z2M2
UniProt Splice Variant
Entrez Gene 3458
UniGene Hs.607204 Hs.856
RefSeq NM_000619
HUGO HGNC:5438
OMIM 147570
CCDS CCDS8980
HPRD
IMGT
EMBL AB451324 AB451453 AF375790 AY255837 BC070256 CH471054 EF173872 J00219 V00543 X01992 X13274
GenPept AAB59534 AAH70256 AAK53058 AAP20098 ABM53145 BAG70138 BAG70267 CAA23804 CAA26022 CAA31639 EAW97180
RNA Seq Atlas 3458