Version 5.4
Homo sapiens Gene: PPP2CA
Summary
InnateDB Gene IDBG-44693.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP2CA
Gene Name protein phosphatase 2, catalytic subunit, alpha isozyme
Synonyms PP2Ac; PP2CA; PP2Calpha; RP-C
Species Homo sapiens
Ensembl Gene ENSG00000113575
Encoded Proteins
IDBP-482184
protein phosphatase 2, catalytic subunit, alpha isozyme
IDBP-475465
protein phosphatase 2, catalytic subunit, alpha isozyme
IDBP-482426
protein phosphatase 2, catalytic subunit, alpha isozyme
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:134194334-134226142
Strand Reverse strand
Band q31.1
Transcripts
ENST00000231504
ENST00000481195 ENSP00000418447
ENST00000472253
ENST00000495833
ENST00000522385 ENSP00000430869
ENST00000523082 ENSP00000428816
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 301 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Experimentally validated
Total 301 [view]
Protein-Protein 296 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
GO:0050811 GABA receptor binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000188 inactivation of MAPK activity
GO:0000278 mitotic cell cycle
GO:0001932 regulation of protein phosphorylation
GO:0006275 regulation of DNA replication
GO:0006355 regulation of transcription, DNA-templated
GO:0006470 protein dephosphorylation
GO:0006672 ceramide metabolic process
GO:0006915 apoptotic process
GO:0007084 mitotic nuclear envelope reassembly
GO:0007126 meiotic nuclear division
GO:0007498 mesoderm development
GO:0008380 RNA splicing
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010033 response to organic substance
GO:0010467 gene expression
GO:0010469 regulation of receptor activity
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0016311 dephosphorylation
GO:0019932 second-messenger-mediated signaling
GO:0030111 regulation of Wnt signaling pathway
GO:0030155 regulation of cell adhesion
GO:0030308 negative regulation of cell growth
GO:0031952 regulation of protein autophosphorylation
GO:0040008 regulation of growth
GO:0042176 regulation of protein catabolic process
GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0045595 regulation of cell differentiation
GO:0070208 protein heterotrimerization
GO:0071902 positive regulation of protein serine/threonine kinase activity
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0000775 chromosome, centromeric region
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020349
View Gene Order
ENSBTAG00000000469
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_8
Wnt pathway
NetPath_15
IL3 pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_150182
MASTL Facilitates Mitotic Progression pathway
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_160242
Initiation of Nuclear Envelope Reformation pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_329
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_1857
Cyclin A/B1 associated events during G2/M transition pathway
REACT_12436
ERKs are inactivated pathway
REACT_12599
ERK/MAPK targets pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_19405
CTLA4 inhibitory signaling pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_23879
Platelet sensitization by LDL pathway
REACT_23876
Platelet homeostasis pathway
REACT_15334
DARPP-32 events pathway
REACT_15295
Opioid Signalling pathway
REACT_111080
Spry regulation of FGF signaling pathway
REACT_111184
Negative regulation of FGFR signaling pathway
REACT_9470
Signaling by FGFR pathway
REACT_11065
Beta-catenin phosphorylation cascade pathway
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_1383
Glycolysis pathway
REACT_705
PP2A-mediated dephosphorylation of key metabolic factors pathway
REACT_1505
Integration of energy metabolism pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_1590
G1 Phase pathway
REACT_11061
Signalling by NGF pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_200610
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_1783
G1/S Transition pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_2203
G2/M Transition pathway
REACT_765
Mitotic Prophase pathway
REACT_160113
Nuclear Envelope Reassembly pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_12433
Nuclear Events (kinase and transcription factor activation) pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_111217
Metabolism pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_71
Gene Expression pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
REACT_604
Hemostasis pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
hsa04530
Tight junction pathway
hsa04730
Long-term depression pathway
hsa04114
Oocyte meiosis pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa03015
mRNA surveillance pathway pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
il8cxcr2_pathway
IL8- and CXCR2-mediated signaling events
rb_1pathway
Regulation of retinoblastoma protein
erbb1_downstream_pathway
ErbB1 downstream signaling
p53regulationpathway
p53 pathway
myc_pathway
C-MYC pathway
tgfbrpathway
TGF-beta receptor signaling
atr_pathway
ATR signaling pathway
pdgfrbpathway
PDGFR-beta signaling pathway
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.713660 Hs.713988
RefSeq NM_002715
HUGO
OMIM
CCDS CCDS4173
HPRD 08912
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca