Homo sapiens Gene: TRAF3 | |||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-21240.6 | ||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||
Gene Symbol | TRAF3 | ||||||||||||||||||||||||||||||||||||
Gene Name | TNF receptor-associated factor 3 | ||||||||||||||||||||||||||||||||||||
Synonyms | CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1 | ||||||||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000131323 | ||||||||||||||||||||||||||||||||||||
Encoded Proteins |
TNF receptor-associated factor 3
TNF receptor-associated factor 3
TNF receptor-associated factor 3
TNF receptor-associated factor 3
TNF receptor-associated factor 3
TNF receptor-associated factor 3
TNF receptor-associated factor 3
TNF receptor-associated factor 3
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Protein Structure | |||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||||||||||
Summary |
TRAF3 serves as a negative regulator of the non-canonical NF-kappaB pathway by specifically blocking the activation of NF-kappaB via TRAF2/5.
TRAF3 is required for type I interferon production in response to intracellular double-stranded RNA. Similarly, a direct and specific interaction of the TRAF domain of TRAF3 with the TRAF-interaction motif (TIM) of MAVS is required for optimal MAVS-mediated antiviral responses.
TRAF3 is a major regulator of type I interferon (IFN) production and the innate antiviral response.
TRAF3 cooperates with ZMYND11 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation.
TRAF3 functions downstream of multiple TNF receptors and receptors that induce interferon (IFN)-alpha, IFN-beta, and IFN-lambda production, including Toll-like receptor 3 (TLR3). TLR3-mediated immunity against primary infection by herpes simplex virus-1 (HSV-1) in the central nervous system is critically dependent on TRAF3.
TRAF3 is a highly versatile regulator that positively controls type I interferon production, and negatively regulates MAP kinase activation and alternative NFkB signalling.
Upon sensing dsRNA or dsDNA, TRAF3 interacts with ER-to-Golgi transport proteins to induce MAVS-associated innate immune responses.
Herpes simplex virus 1 protein, UL36 ubiquitin-specific protease (UL36USP), deubiquitinates TRAF3 and inhibits recruitment of TBK1 and counteracts the IFNB pathway
HACE1 plays an inhibitory role in virus-induced signalling by disrupting the MAVS-TRAF3 complex.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||
Summary |
[Mus musculus] Traf3 is a component of Toll/interleukin-1 receptor (TIR) signalling complexes that is recruited along with Traf6. Traf3 is essential for the induction of type I interferons (IFN) and the anti-inflammatory cytokine interleukin 10, but is dispensable for expression of pro-inflammatory cytokines.
[Mus musculus] Traf3 is a highly versatile regulator that positively controls type I interferon production, and negatively regulates MAP kinase activation and alternative NFkB signalling.
[Mus musculus] Upon sensing dsRNA or dsDNA, Traf3 interacts with ER-to-Golgi transport proteins to induce Mavs-associated innate immune responses. (Demonstrated in human)
[Mus musculus] Traf3 expressed in myeloid cells regulates immune responses in myeloid cells and acts to inhibit inflammation and tumor development.
[Mus musculus] Usp25 physically associates with Traf3 and Traf6 after infection by RNA or DNA viruses and promotes innate antiviral responses by protecting virus-induced proteasome-dependent or independent degradation of Traf3 and Traf6.
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Entrez Gene | |||||||||||||||||||||||||||||||||||||
Summary |
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. [provided by RefSeq, Dec 2010] |
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Gene Information | |||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 14:102777476-102911500 | ||||||||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||||||||
Band | q32.32 | ||||||||||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 195 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||||||
NETPATH |
TNFalpha pathway
RANKL pathway
TWEAK pathway
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REACTOME |
Negative regulators of RIG-I/MDA5 signaling pathway
TRAF3-dependent IRF activation pathway pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
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KEGG |
Small cell lung cancer pathway
Toll-like receptor signaling pathway pathway
Pathways in cancer pathway
RIG-I-like receptor signaling pathway pathway
Hepatitis C pathway
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INOH | |||||||||||||||||||||||||||||||||||||
PID NCI |
CD40/CD40L signaling
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Cross-References | |||||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||||
TrEMBL | H0YL25 | ||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||
Entrez Gene | 7187 | ||||||||||||||||||||||||||||||||||||
UniGene | Hs.510528 Hs.599754 Hs.732634 | ||||||||||||||||||||||||||||||||||||
RefSeq | NM_001199427 NM_003300 NM_145725 NM_145726 XM_006720244 | ||||||||||||||||||||||||||||||||||||
HUGO | HGNC:12033 | ||||||||||||||||||||||||||||||||||||
OMIM | 601896 | ||||||||||||||||||||||||||||||||||||
CCDS | CCDS55946 CCDS9975 CCDS9976 | ||||||||||||||||||||||||||||||||||||
HPRD | 03539 | ||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||
EMBL | AL117209 AL132801 | ||||||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | 7187 | ||||||||||||||||||||||||||||||||||||