Homo sapiens Gene: IKBKB
Summary
InnateDB Gene IDBG-19987.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IKBKB
Gene Name inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Synonyms IKK-beta; IKK2; IKKB; IMD15; NFKBIKB;
Species Homo sapiens
Ensembl Gene ENSG00000104365
Encoded Proteins
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IKBKB regulates late-phase allergic reactions promoted by the release of pro-inflammatory cytokines in an NF-kappaB-dependent manner.
Phosphorylated IKBKB is conjugated with a monoubiquitin by the E3 ubiquitin ligase TRIM21 leading to down-regulatioin of IKBKB-induced NF-kappaB signalling. The TRIM21-mediated monoubiquitination is involved in the translocation of active IKBKB to autophagosomes.
IKBKB and other IKK kinases regulate each other by an intricate network involving phosphorylation of their catalytic and regulatory (NEMO, TANK) subunits to balance their activities during innate immunity.
GNB2L1 (RACK1) negatively regulates NFκB activation by interacting with CHUK and IKBKB. The interaction interferes with the recruitment of the IKK complex to TRAF2 .
The reversible ubiquitin editing of NLRC5 determines NLRC5?? IKBKB interaction dynamics and plays a crucial role in precisely regulating NFκB signalling
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Ikbkb and other IKK kinases regulate each other by an intricate network involving phosphorylation of their catalytic and regulatory (NEMO, TANK) subunits to balance their activities during innate immunity.
[Mus musculus] The reversible ubiquitin editing of Nlrc5 determines Nlrc5?? Ikbkb interaction dynamics and plays a crucial role in precisely regulating NFκB signalling
Entrez Gene
Summary The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:42271302-42332653
Strand Forward strand
Band p11.21
Transcripts
ENST00000342222 ENSP00000339151
ENST00000416505 ENSP00000404920
ENST00000520810 ENSP00000430684
ENST00000520320 ENSP00000429699
ENST00000517890 ENSP00000428799
ENST00000519733 ENSP00000429319
ENST00000519735 ENSP00000430483
ENST00000523105 ENSP00000429239
ENST00000520835 ENSP00000430868
ENST00000517917
ENST00000518679 ENSP00000430557
ENST00000518983 ENSP00000427978
ENST00000520201
ENST00000517388 ENSP00000429924
ENST00000518647
ENST00000521661 ENSP00000428186
ENST00000520655 ENSP00000428922
ENST00000517812 ENSP00000429357
ENST00000522147 ENSP00000428892
ENST00000523517 ENSP00000430114
ENST00000522545
ENST00000517502
ENST00000522785
ENST00000519938
ENST00000522133
ENST00000523018
ENST00000523599
ENST00000521225
ENST00000522103
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 300 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Experimentally validated
Total 300 [view]
Protein-Protein 297 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008384 IkappaB kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019901 protein kinase binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0097110 scaffold protein binding
Biological Process
GO:0001782 B cell homeostasis
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007252 I-kappaB phosphorylation
GO:0009103 lipopolysaccharide biosynthetic process
GO:0009615 response to virus
GO:0010765 positive regulation of sodium ion transport
GO:0032481 positive regulation of type I interferon production
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042501 serine phosphorylation of STAT protein
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0071356 cellular response to tumor necrosis factor
GO:2001259 positive regulation of cation channel activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008385 IkappaB kinase complex
GO:0009898 cytoplasmic side of plasma membrane
GO:0016020 membrane
GO:0035631 CD40 receptor complex
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TGF_beta_Receptor pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL1 pathway
IL4 pathway
RANKL pathway
Leptin pathway
TSH pathway
TWEAK pathway
IL11 pathway
REACTOME
RIP-mediated NFkB activation via ZBP1 pathway
MyD88 dependent cascade initiated on endosome pathway
FCERI mediated NF-kB activation pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
p75NTR recruits signalling complexes pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TCR signaling pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
MyD88 cascade initiated on plasma membrane pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
NF-kB is activated and signals survival pathway
IKK complex recruitment mediated by RIP1 pathway
IRAK1 recruits IKK complex pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
TRAF6 mediated NF-kB activation pathway
Fc epsilon receptor (FCERI) signaling pathway
p75 NTR receptor-mediated signalling pathway
p75NTR signals via NF-kB pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Signal Transduction pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
Activation of NF-kappaB in B cells pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Adaptive Immune System pathway
NOD1/2 Signaling Pathway pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Immune System pathway
MyD88-independent cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Signaling by Interleukins pathway
Downstream TCR signaling pathway
Interleukin-1 signaling pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Cytosolic sensors of pathogen-associated DNA pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
KEGG
MAPK signaling pathway pathway
Chemokine signaling pathway pathway
mTOR signaling pathway pathway
Apoptosis pathway
Osteoclast differentiation pathway
Toll-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Type II diabetes mellitus pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Shigellosis pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
Pathways in cancer pathway
Pancreatic cancer pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Small cell lung cancer pathway
INOH
TNFR1 signaling pathway pathway
IL-7 signaling pathway
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Toll-like receptor pathway [Biocarta view]
Chaperones modulate interferon signaling pathway [Biocarta view]
Nf-kb signaling pathway [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Bone remodeling [Biocarta view]
Double stranded rna induced gene expression [Biocarta view]
Trefoil factors initiate mucosal healing [Biocarta view]
Signal transduction through il1r [Biocarta view]
Tnf/stress related signaling [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
Ceramide signaling pathway [Biocarta view]
Nfkb activation by nontypeable hemophilus influenzae [Biocarta view]
Influence of ras and rho proteins on g1 to s transition [Biocarta view]
PID NCI
Atypical NF-kappaB pathway
TCR signaling in nave CD8+ T cells
TCR signaling in nave CD4+ T cells
IL1-mediated signaling events
TNF receptor signaling pathway
TRAIL signaling pathway
mTOR signaling pathway
FoxO family signaling
p75(NTR)-mediated signaling
BCR signaling pathway
Canonical NF-kappaB pathway
GMCSF-mediated signaling events
Validated transcriptional targets of TAp63 isoforms
Fc-epsilon receptor I signaling in mast cells
Endogenous TLR signaling
FAS (CD95) signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.597664 Hs.715799
RefSeq NM_001190720 NM_001242778 NM_001556 XM_005273492
HUGO
OMIM
CCDS CCDS55228 CCDS56535 CCDS6128
HPRD 04462
IMGT
EMBL
GenPept
RNA Seq Atlas