Version 5.4
| Mus musculus Gene: Clec4e | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-186402.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | Clec4e | ||||||||||||||||||
| Gene Name | C-type lectin domain family 4, member e | ||||||||||||||||||
| Synonyms | C86253; Clecsf9; Mincle | ||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||
| Ensembl Gene | ENSMUSG00000030142 | ||||||||||||||||||
| Encoded Proteins |
C-type lectin domain family 4, member e
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
Clec4e, a C-type lectin receptor, is a pattern recognition receptor critical for immune responses to fungi. Clec4e is coupled to Syk kinase and signals via Card9 to activate NFKB, which in turns induces both innate and adaptive immunity.
The expression of Clec4e (Mincle) and its downstream signal phospho-Syk/Syk increases after cerebral ischemia and reperfusion.
Clec4d is an inducible myeloid-expressed C-type lectin receptor, whose expression is tightly linked to that of Clec4e.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||
| Summary |
[Homo sapiens] CLEC4E, a C-type lectin receptor, is a pattern recognition receptor critical for immune responses to fungi. CLEC4E is coupled to SYK kinase and signals via CARD9 to activate NFKB, which in turns induces both innate and adaptive immunity.
[Homo sapiens] Glycerol monomycolate is a unique ligand for CLEC4E (Mincle).
[Homo sapiens] Cholesterol crystals are an endogenous ligand for CLEC4E and their binding activates innate immune responses.
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| Entrez Gene | |||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166523:
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 6:123281789-123289870 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | F2 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||||||||||||
| SwissProt | Q9R0Q8 | ||||||||||||||||||
| TrEMBL | H3BJQ5 H3BL75 Q4FK29 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 56619 | ||||||||||||||||||
| UniGene | Mm.248327 Mm.416157 | ||||||||||||||||||
| RefSeq | NM_019948 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS20514 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| MGI ID | MGI:1861232 | ||||||||||||||||||
| MGI Symbol | Clec4e | ||||||||||||||||||
| EMBL | AB024717 AC124563 AK150528 AK150899 AK151101 AK151912 AK153008 AK153308 AK156437 AK170698 AK171103 BC003218 CH466523 CT010223 | ||||||||||||||||||
| GenPept | AAH03218 BAA83754 BAE29637 BAE29944 BAE30111 BAE30792 BAE31647 BAE31889 BAE33711 BAE41962 BAE42251 CAJ18431 EDK99715 | ||||||||||||||||||
| RNA Seq Atlas | 56619 | ||||||||||||||||||