InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prkra

Summary

InnateDB Gene

IDBG-182095.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prkra

Gene Name

protein kinase, interferon inducible double stranded RNA dependent activator

Synonyms

AV120107; lear; Pact; PRK; RAX

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002731

Encoded Proteins

IDBP-182097

protein kinase, interferon inducible double stranded RNA dependent activator

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25784705

[Homo sapiens] The G3BP1-CAPRIN1-PRKRA complex represents a new mode of PRKRA activation and links stress responses with innate immune activation through PRKRA without a requirement for foreign double-stranded RNA pattern recognition.

PMID 26608320

[Homo sapiens] A defective interfering RNA isolated from the Hu-191 vaccine strain of measles virus is sensed by PRKRA and DDX58 to initiate an innate antiviral response.

PMID 26454002

[Homo sapiens] DDX3X participates in antiviral innate immunity by controlling translation of PRKRA.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180228:
This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:76629898-76648015

Strand

Reverse strand

Band

Transcripts

ENSMUST00000002808	ENSMUSP00000002808
ENSMUST00000140493

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006468	protein phosphorylation
GO:0030422	production of siRNA involved in RNA interference
GO:0034599	cellular response to oxidative stress
GO:0042473	outer ear morphogenesis
GO:0042474	middle ear morphogenesis
GO:0048705	skeletal system morphogenesis
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway