InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Irf1

Summary

InnateDB Gene

IDBG-172251.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irf1

Gene Name

interferon regulatory factor 1

Synonyms

AU020929; Irf-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018899

Encoded Proteins

IDBP-172255

interferon regulatory factor 1

IDBP-263500

interferon regulatory factor 1

IDBP-263502

interferon regulatory factor 1

IDBP-541656

interferon regulatory factor 1

IDBP-532223

interferon regulatory factor 1

IDBP-536092

interferon regulatory factor 1

IDBP-533210

interferon regulatory factor 1

IDBP-538724

interferon regulatory factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21097874

Irf1 transcriptionally inhibits the Il23a through the ISRE element and reduce the severity of chronic intestinal inflammation caused by LPS.

PMID 22266972

Irf1 promotes immune cell apoptosis and inhibits autophagy in a murine endotoxemia model.

PMID 24675692

Irf1 is an essential regulator of the host innate antiviral response in the brain by limiting viral replication at later stages of infection, but is not involved in the rapid induction of IFN.

PMID 26305961

Nlrp3 deficiency protects mice from the development of type 1 diabetes by suppressing Th1 responses and impairing T-cell migration to pancreatic islets through the down-regulation of chemokine expression (Ccl5, Cxcl10, Irf1) in islets.

InnateDB Annotation from Orthologs

Summary

PMID 12759449

[Homo sapiens] IRF1 is required for the up-regulation of the CD40-NF-kappaB activator 1 (TRAF3IP2 ) axis during airway inflammation.

PMID 12420214

[Homo sapiens] IRF1 is controlled by two distinct signalling pathways; a JAK/STAT-signalling pathway in viral infected cells and an ATM-signalling pathway in DNA damaged cells.

PMID 3409321

[Homo sapiens] IRF1 specifically binds to the upstream regulatory region of the human IFN-beta (IFNB1) gene and mediates IFNB1 virus-induced transcription and is involved in the regulation of other genes such as IFN-alpha and MHC class I genes.

PMID 20308629

[Homo sapiens] IRF1 mediated type I IFN independent mechanism of enhanced RSAD2 (viperin) expression provides a redundant mechanism to protect cells from viral infections.

PMID 21097874

[Homo sapiens] IRF1 transcriptionally inhibits the IL23A through the ISRE element and reduce the severity of chronic intestinal inflammation caused by LPS (shown in mice).

PMID 22266972

[Homo sapiens] IRF1 promotes immune cell apoptosis and inhibits autophagy in a murine endotoxemia model. (Demonstrated in mice)

PMID 25461762

[Homo sapiens] MIR23A contributes to human herpes simplex virus type 1 replication through the regulation of the IRF1-mediated antiviral signal pathway.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125347:
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:53770014-53778374

Strand

Forward strand

Band

B1.3

Transcripts

ENSMUST00000019043	ENSMUSP00000019043
ENSMUST00000108922	ENSMUSP00000104550
ENSMUST00000108920	ENSMUSP00000104548
ENSMUST00000140866	ENSMUSP00000114315
ENSMUST00000128336
ENSMUST00000142221	ENSMUSP00000118795
ENSMUST00000138913	ENSMUSP00000118314
ENSMUST00000123376	ENSMUSP00000122101
ENSMUST00000133291	ENSMUSP00000116656
ENSMUST00000153054

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 120 interaction(s) predicted by orthology.

Experimentally validated
Total	83 [view]
Protein-Protein	22 [view]
Protein-DNA	61 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	120 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0002819	regulation of adaptive immune response
GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0007050	cell cycle arrest
GO:0010468	regulation of gene expression
GO:0032481	positive regulation of type I interferon production
GO:0032728	positive regulation of interferon-beta production
GO:0032825	positive regulation of natural killer cell differentiation
GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0035458	cellular response to interferon-beta
GO:0043374	CD8-positive, alpha-beta T cell differentiation
GO:0045084	positive regulation of interleukin-12 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045088	regulation of innate immune response
GO:0045590	negative regulation of regulatory T cell differentiation
GO:0045627	positive regulation of T-helper 1 cell differentiation
GO:0045629	negative regulation of T-helper 2 cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051607	defense response to virus
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0071260	cellular response to mechanical stimulus
GO:2000564	regulation of CD8-positive, alpha-beta T cell proliferation