Mus musculus Gene: Irf1
Summary
InnateDB Gene IDBG-172251.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irf1
Gene Name interferon regulatory factor 1
Synonyms AU020929; Irf-1;
Species Mus musculus
Ensembl Gene ENSMUSG00000018899
Encoded Proteins
interferon regulatory factor 1
interferon regulatory factor 1
interferon regulatory factor 1
interferon regulatory factor 1
interferon regulatory factor 1
interferon regulatory factor 1
interferon regulatory factor 1
interferon regulatory factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Irf1 transcriptionally inhibits the Il23a through the ISRE element and reduce the severity of chronic intestinal inflammation caused by LPS.
Irf1 promotes immune cell apoptosis and inhibits autophagy in a murine endotoxemia model.
Irf1 is an essential regulator of the host innate antiviral response in the brain by limiting viral replication at later stages of infection, but is not involved in the rapid induction of IFN.
Nlrp3 deficiency protects mice from the development of type 1 diabetes by suppressing Th1 responses and impairing T-cell migration to pancreatic islets through the down-regulation of chemokine expression (Ccl5, Cxcl10, Irf1) in islets.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] IRF1 is required for the up-regulation of the CD40-NF-kappaB activator 1 (TRAF3IP2 ) axis during airway inflammation.
[Homo sapiens] IRF1 is controlled by two distinct signalling pathways; a JAK/STAT-signalling pathway in viral infected cells and an ATM-signalling pathway in DNA damaged cells.
[Homo sapiens] IRF1 specifically binds to the upstream regulatory region of the human IFN-beta (IFNB1) gene and mediates IFNB1 virus-induced transcription and is involved in the regulation of other genes such as IFN-alpha and MHC class I genes.
[Homo sapiens] IRF1 mediated type I IFN independent mechanism of enhanced RSAD2 (viperin) expression provides a redundant mechanism to protect cells from viral infections.
[Homo sapiens] IRF1 transcriptionally inhibits the IL23A through the ISRE element and reduce the severity of chronic intestinal inflammation caused by LPS (shown in mice).
[Homo sapiens] IRF1 promotes immune cell apoptosis and inhibits autophagy in a murine endotoxemia model. (Demonstrated in mice)
[Homo sapiens] MIR23A contributes to human herpes simplex virus type 1 replication through the regulation of the IRF1-mediated antiviral signal pathway.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125347:
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:53770014-53778374
Strand Forward strand
Band B1.3
Transcripts
ENSMUST00000019043 ENSMUSP00000019043
ENSMUST00000108922 ENSMUSP00000104550
ENSMUST00000108920 ENSMUSP00000104548
ENSMUST00000140866 ENSMUSP00000114315
ENSMUST00000128336
ENSMUST00000142221 ENSMUSP00000118795
ENSMUST00000138913 ENSMUSP00000118314
ENSMUST00000123376 ENSMUSP00000122101
ENSMUST00000133291 ENSMUSP00000116656
ENSMUST00000153054
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 120 interaction(s) predicted by orthology.
Experimentally validated
Total 83 [view]
Protein-Protein 22 [view]
Protein-DNA 61 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 120 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0002819 regulation of adaptive immune response
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0007050 cell cycle arrest
GO:0010468 regulation of gene expression
GO:0032481 positive regulation of type I interferon production
GO:0032728 positive regulation of interferon-beta production
GO:0032825 positive regulation of natural killer cell differentiation
GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0035458 cellular response to interferon-beta
GO:0043374 CD8-positive, alpha-beta T cell differentiation
GO:0045084 positive regulation of interleukin-12 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045088 regulation of innate immune response
GO:0045590 negative regulation of regulatory T cell differentiation
GO:0045627 positive regulation of T-helper 1 cell differentiation
GO:0045629 negative regulation of T-helper 2 cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0071260 cellular response to mechanical stimulus
GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Hemostasis pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
TRAF6 mediated IRF7 activation pathway
Factors involved in megakaryocyte development and platelet production pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
KEGG
Hepatitis C pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
TRAF6 mediated IRF7 activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Interferon Signaling pathway
Immune System pathway
Interferon gamma signaling pathway
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
Factors involved in megakaryocyte development and platelet production pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Hemostasis pathway
Immune System pathway
TRAF6 mediated IRF7 activation pathway
Innate Immune System pathway
KEGG
Hepatitis C pathway
INOH
PID BIOCARTA
The information processing pathway at the ifn beta enhancer [Biocarta view]
PID NCI
IL12 signaling mediated by STAT4
Glucocorticoid receptor regulatory network
IL6-mediated signaling events
Regulation of Telomerase
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.399626
RefSeq NM_001159393 NM_001159396 NM_008390 XM_006532308
OMIM
CCDS CCDS24686 CCDS48796
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas