Mus musculus Gene: Nfkbiz
Summary
InnateDB Gene IDBG-165943.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nfkbiz
Gene Name nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
Synonyms AA408868; INAP; Mail;
Species Mus musculus
Ensembl Gene ENSMUSG00000035356
Encoded Proteins
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Tet2 selectively mediates active repression of Il6 transcription via Nfkbiz and Hdac2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] Inhibits the DNA binding of RELA and NFKB1
[Homo sapiens] A key regulator of IL-6 production in human monocytes and plays an important role in both TLR and NOD-like receptor ligand induced inflammation
[Homo sapiens] IFNG interferes with the IL-1/NFKBIZ axis in β-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFNG and IL22, and diminished production of IL17A.
[Homo sapiens] TET2 selectively mediates active repression of IL6 transcription via NFKBIZ and HDAC2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144802:
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:55811375-55838899
Strand Reverse strand
Band C1.1
Transcripts
ENSMUST00000036273 ENSMUSP00000041173
ENSMUST00000096026 ENSMUSP00000093726
ENSMUST00000114458 ENSMUSP00000110102
ENSMUST00000114457 ENSMUSP00000110101
ENSMUST00000139373
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 5 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006954 inflammatory response
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9EST8
TrEMBL
UniProt Splice Variant
Entrez Gene 80859
UniGene Mm.247272
RefSeq NM_030612 NM_001159394 NM_001159395
OMIM
CCDS CCDS28216 CCDS49869
HPRD
IMGT
MGI ID MGI:1931595
MGI Symbol Nfkbiz
EMBL AB020974 AB026551 AB040458 AB047549 AB196497 AK082908 AK136509 AK141318 AK150519 AK152016 AK159093 AK159171 AK159459 AK159645 AK159917 AK160065 BC058188
GenPept AAH58188 BAA95161 BAB18302 BAB32782 BAB85809 BAC38681 BAD82955 BAE23017 BAE24648 BAE29631 BAE30878 BAE34809 BAE34871 BAE35101 BAE35257 BAE35480 BAE35601
RNA Seq Atlas 80859