Version 5.4
Mus musculus Gene: Hdac2
Summary
InnateDB Gene IDBG-143980.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hdac2
Gene Name histone deacetylase 2
Synonyms D10Wsu179e; mRPD3; YAF1; Yy1bp
Species Mus musculus
Ensembl Gene ENSMUSG00000019777
Encoded Proteins
IDBP-143982
histone deacetylase 2
IDBP-270731
histone deacetylase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26287468
Tet2 selectively mediates active repression of Il6 transcription via Nfkbiz and Hdac2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.
InnateDB Annotation from Orthologs
Summary
PMID 20798038
[Homo sapiens] Histone deacetylase 2 (HDAC2) is part of a repressor complex, along with key components that include HDAC1, RE-1 silencing transcription factor (REST), co-repressor of REST (CoREST), and lysine-specific demethylase (LSD) 1. The HDAC/CoREST/REST/LSD1 repressor complex is a significant component of host innate immunity.
PMID 26287468
[Homo sapiens] TET2 selectively mediates active repression of IL6 transcription via NFKBIZ and HDAC2 during inflammation resolution in innate myeloid cells, including dendritic cells and macrophages.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196591:
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:36974544-37001889
Strand Forward strand
Band B1
Transcripts
ENSMUST00000019911 ENSMUSP00000019911
ENSMUST00000105510 ENSMUSP00000101149
ENSMUST00000128031
ENSMUST00000123010
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 94 experimentally validated interaction(s) in this database.
They are also associated with 354 interaction(s) predicted by orthology.
Experimentally validated
Total 94 [view]
Protein-Protein 82 [view]
Protein-DNA 11 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 354 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019213 deacetylase activity
GO:0019899 enzyme binding
GO:0031072 heat shock protein binding
GO:0031490 chromatin DNA binding
GO:0031492 nucleosomal DNA binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558 protein deacetylase activity
GO:0035851 Krueppel-associated box domain binding
GO:0043565 sequence-specific DNA binding
GO:0044822 poly(A) RNA binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006344 maintenance of chromatin silencing
GO:0006351 transcription, DNA-templated
GO:0006476 protein deacetylation
GO:0008284 positive regulation of cell proliferation
GO:0009913 epidermal cell differentiation
GO:0010870 positive regulation of receptor biosynthetic process
GO:0010977 negative regulation of neuron projection development
GO:0016358 dendrite development
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0021766 hippocampus development
GO:0030182 neuron differentiation
GO:0032922 circadian regulation of gene expression
GO:0034605 cellular response to heat
GO:0042220 response to cocaine
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042493 response to drug
GO:0042733 embryonic digit morphogenesis
GO:0043044 ATP-dependent chromatin remodeling
GO:0043066 negative regulation of apoptotic process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087 innate immune response (InnateDB)
GO:0045862 positive regulation of proteolysis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051896 regulation of protein kinase B signaling
GO:0055013 cardiac muscle cell development
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060297 regulation of sarcomere organization
GO:0060789 hair follicle placode formation
GO:0061029 eyelid development in camera-type eye
GO:0061198 fungiform papilla formation
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090311 regulation of protein deacetylation
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0000118 histone deacetylase complex
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005657 replication fork
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0017053 transcriptional repressor complex
GO:0035098 ESC/E(Z) complex
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000196591
View Gene Order
ENSBTAG00000011849
Not yet available
Pathways
NETPATH
REACTOME
REACT_245058
RNA Polymerase I Transcription pathway
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_200794
Mus musculus biological processes pathway
REACT_200667
NoRC negatively regulates rRNA expression pathway
REACT_218274
Chromatin organization pathway
REACT_224553
Hemostasis pathway
REACT_214440
NoRC negatively regulates rRNA expression pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_248921
Signalling by NGF pathway
REACT_233572
Gene Expression pathway
REACT_207809
Negative epigenetic regulation of rRNA expression pathway
REACT_188257
Signal Transduction pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
REACT_257106
HDACs deacetylate histones pathway
REACT_240511
RNA Polymerase I Promoter Clearance pathway
REACT_202086
p75NTR negatively regulates cell cycle via SC1 pathway
REACT_235780
RNA Polymerase I Transcription Initiation pathway
KEGG
mmu04330
Notch signaling pathway pathway
mmu04110
Cell cycle pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05016
Huntington's disease pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_3
Notch pathway
NetPath_9
TNFalpha pathway
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_13695
p75NTR negatively regulates cell cycle via SC1 pathway
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_11061
Signalling by NGF pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_111102
Signal Transduction pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_172623
Chromatin organization pathway
REACT_299
Signaling by NOTCH pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
REACT_604
Hemostasis pathway
KEGG
hsa04110
Cell cycle pathway
hsa04330
Notch signaling pathway pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05016
Huntington's disease pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
TGF-beta signaling pathway
PID NCI
p53downstreampathway
Direct p53 effectors
hdac_classi_pathway
Signaling events mediated by HDAC Class I
reg_gr_pathway
Glucocorticoid receptor regulatory network
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.19806 Mm.408743
RefSeq NM_008229
OMIM
CCDS CCDS23783
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca