|Homo sapiens Gene: MIR223|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||microRNA 223|
|Useful resources||Stemformatics EHFPI ImmGen|
MIR223 negatively regulates NLRP3 inflammasome activity.
MIR223 regulates the NLRP3 inflammasome and IL-1β production.
MIR223 regulates macrophage function by modulating cytokine production and NF-κB activation through inhibition of RELA phosphorylation and nuclear translocation.
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|Genomic Location||Chromosome X:66018870-66018979|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
|No orthologs found for this gene|
|UniProt Splice Variant|
|RNA Seq Atlas||407008|