Homo sapiens Gene: IKBKB
Summary
InnateDB Gene IDBG-108066.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol IKBKB
Gene Name inhibitor of nuclear factor kappa B kinase subunit beta
Synonyms IKK-beta; IKK2; IKKB; IMD15; NFKBIKB
Species Homo sapiens
Ensembl Gene ENSG00000104365
Encoded Proteins
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
inhibitor of nuclear factor kappa B kinase subunit beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IKBKB regulates late-phase allergic reactions promoted by the release of pro-inflammatory cytokines in an NF-kappaB-dependent manner.
Phosphorylated IKBKB is conjugated with a monoubiquitin by the E3 ubiquitin ligase TRIM21 leading to down-regulatioin of IKBKB-induced NF-kappaB signalling. The TRIM21-mediated monoubiquitination is involved in the translocation of active IKBKB to autophagosomes.
IKBKB and other IKK kinases regulate each other by an intricate network involving phosphorylation of their catalytic and regulatory (NEMO, TANK) subunits to balance their activities during innate immunity.
GNB2L1 (RACK1) negatively regulates NFκB activation by interacting with CHUK and IKBKB. The interaction interferes with the recruitment of the IKK complex to TRAF2 .
The reversible ubiquitin editing of NLRC5 determines NLRC5?? IKBKB interaction dynamics and plays a crucial role in precisely regulating NFκB signalling
Enterovirus 71 2C protein binds to RELA and IKBKB to inhibit NF-kB activation and evade innate immune defenses.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Ikbkb and other IKK kinases regulate each other by an intricate network involving phosphorylation of their catalytic and regulatory (NEMO, TANK) subunits to balance their activities during innate immunity.
[Mus musculus] The reversible ubiquitin editing of Nlrc5 determines Nlrc5?? Ikbkb interaction dynamics and plays a crucial role in precisely regulating NFκB signalling
Entrez Gene
Summary The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:42271302-42332653
Strand Forward strand
Band p11.21
Transcripts
ENST00000342222 ENSP00000339151
ENST00000416505 ENSP00000404920
ENST00000517388 ENSP00000429924
ENST00000517502
ENST00000517812 ENSP00000429357
ENST00000517890 ENSP00000428799
ENST00000517917
ENST00000518647
ENST00000518679 ENSP00000430557
ENST00000518983 ENSP00000427978
ENST00000519733 ENSP00000429319
ENST00000519735 ENSP00000430483
ENST00000519938
ENST00000520201
ENST00000520320 ENSP00000429699
ENST00000520655 ENSP00000428922
ENST00000520810 ENSP00000430684
ENST00000520835 ENSP00000430868
ENST00000521225
ENST00000521661 ENSP00000428186
ENST00000522103
ENST00000522133
ENST00000522147 ENSP00000428892
ENST00000522545
ENST00000522785
ENST00000523018
ENST00000523105 ENSP00000429239
ENST00000523517 ENSP00000430114
ENST00000523599
ENST00000629753 ENSP00000486961
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 377 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Experimentally validated
Total 354 [view]
Protein-Protein 299 [view]
Protein-DNA 55 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 48 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008384 IkappaB kinase activity
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0097110 scaffold protein binding
Biological Process
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007252 I-kappaB phosphorylation
GO:0009615 response to virus
GO:0009653 anatomical structure morphogenesis
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0030866 cortical actin cytoskeleton organization
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042325 regulation of phosphorylation
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071356 cellular response to tumor necrosis factor
GO:0072659 protein localization to plasma membrane
GO:1903140 regulation of establishment of endothelial barrier
GO:1903347 negative regulation of bicellular tight junction assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008385 IkappaB kinase complex
GO:0009898 cytoplasmic side of plasma membrane
GO:0016020 membrane
GO:0035631 CD40 receptor complex
GO:0045121 membrane raft
Orthologs
Species
Bos taurus
Mus musculus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
RANKL pathway
IL1 pathway
TCR pathway
BCR pathway
TWEAK pathway
Leptin pathway
TNFalpha pathway
IL4 pathway
TSH pathway
TGF_beta_Receptor pathway
REACTOME
Diseases associated with the TLR signaling cascade pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
p75NTR recruits signalling complexes pathway
Death Receptor Signalling pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
p75 NTR receptor-mediated signalling pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
FCERI mediated NF-kB activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) pathway
IkBA variant leads to EDA-ID pathway
Toll-Like Receptors Cascades pathway
NF-kB is activated and signals survival pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
IRAK1 recruits IKK complex pathway
Interleukin-17 signaling pathway
TNFR1-induced NFkappaB signaling pathway pathway
Signaling by the B Cell Receptor (BCR) pathway
Interleukin-1 family signaling pathway
Antigen processing-Cross presentation pathway
ER-Phagosome pathway pathway
p75NTR signals via NF-kB pathway
Signaling by Interleukins pathway
MAP3K8 (TPL2)-dependent MAPK1/3 activation pathway
Signal Transduction pathway
IKK complex recruitment mediated by RIP1 pathway
Activation of NF-kappaB in B cells pathway
Immune System pathway
NOD1/2 Signaling Pathway pathway
TNF signaling pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
MAP kinase activation pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
TCR signaling pathway
CLEC7A (Dectin-1) signaling pathway
Interleukin-1 signaling pathway
TRIF(TICAM1)-mediated TLR4 signaling pathway
Downstream TCR signaling pathway
TRAF6 mediated NF-kB activation pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
Innate Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway
Cytosolic sensors of pathogen-associated DNA pathway
MyD88 cascade initiated on plasma membrane pathway
DDX58/IFIH1-mediated induction of interferon-alpha/beta pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
TICAM1, RIP1-mediated IKK complex recruitment pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
MyD88-independent TLR4 cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Cytokine Signaling in Immune system pathway
Adaptive Immune System pathway
IKBKB deficiency causes SCID pathway
Disease pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Regulation of TNFR1 signaling pathway
MyD88:Mal cascade initiated on plasma membrane pathway
RIP-mediated NFkB activation via ZBP1 pathway
Diseases of Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
C-type lectin receptors (CLRs) pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
KEGG
MAPK signaling pathway pathway
Ras signaling pathway pathway
Chemokine signaling pathway pathway
NF-kappa B signaling pathway pathway
FoxO signaling pathway pathway
mTOR signaling pathway pathway
PI3K-Akt signaling pathway pathway
Apoptosis pathway
Osteoclast differentiation pathway
Toll-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
C-type lectin receptor signaling pathway pathway
IL-17 signaling pathway pathway
Th1 and Th2 cell differentiation pathway
Th17 cell differentiation pathway
T cell receptor signaling pathway pathway
B cell receptor signaling pathway pathway
TNF signaling pathway pathway
Neurotrophin signaling pathway pathway
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Type II diabetes mellitus pathway
Insulin resistance pathway
Non-alcoholic fatty liver disease (NAFLD) pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Shigellosis pathway
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Hepatitis C pathway
Hepatitis B pathway
Influenza A pathway
Human papillomavirus infection pathway
HTLV-I infection pathway
Kaposi's sarcoma-associated herpesvirus infection pathway
Herpes simplex infection pathway
Epstein-Barr virus infection pathway
Pathways in cancer pathway
MicroRNAs in cancer pathway
Pancreatic cancer pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Acute myeloid leukemia pathway
Small cell lung cancer pathway
Fluid shear stress and atherosclerosis pathway
INOH
TNF.owl pathway
B cell receptor signaling.owl pathway
IL-1 NFkB.owl pathway
EPO signaling.owl pathway
VEGF.owl pathway
TLR NFkB.owl pathway
PID NCI
Endogenous TLR signaling
Fc-epsilon receptor I signaling in mast cells
IL1-mediated signaling events
TRAIL signaling pathway
TCR signaling in nave CD4+ T cells
FoxO family signaling
GMCSF-mediated signaling events
p75(NTR)-mediated signaling
FAS (CD95) signaling pathway
BCR signaling pathway
TCR signaling in nave CD8+ T cells
Validated transcriptional targets of TAp63 isoforms
Canonical NF-kappaB pathway
mTOR signaling pathway
Atypical NF-kappaB pathway
TNF receptor signaling pathway
Cross-References
SwissProt O14920
TrEMBL E5RFG5 E5RFT3 E5RGA0 E5RGW5 E5RIW0 E5RJH2 G3V105 J3KNS5
UniProt Splice Variant
Entrez Gene 3551
UniGene
RefSeq NM_001190720 NM_001242778 NM_001556 XM_005273490 XM_005273491 XM_005273492 XM_005273493 XM_005273494 XM_005273495 XM_005273496 XM_005273498 XM_011544517 XM_011544518 XM_011544519 XM_011544520 XM_011544521 XM_011544522 XM_017013396
HUGO HGNC:5960
OMIM 603258
CCDS CCDS55228 CCDS56535 CCDS6128
HPRD
IMGT
EMBL AC083973 AF029684 AF031416 AF080158 AK302723 AK303528 AK316418 AY663108 BC006231 CH471080 KF458748 KF495673
GenPept AAC51860 AAC64675 AAD08997 AAH06231 AAT65965 BAG63942 BAG64556 BAH14789 EAW63223
RNA Seq Atlas 3551